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KMID : 0370019980120000017
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Chung-Ang Journal of Pharmacal Sciences
1998 Volume.12 No. 0 p.17 ~ p.29
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The Role of Nitric Oxide on the Inflammatory Edema and Pain induced by Carrageenan in the Rat
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Abstract
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To study the role of nitric oxide (NO) on the inflammatory edema and pain, we have measured the paw volume and mechanical nociceptive threshold change ratio. In periphery, L-NAME (NO synthase inhibitor) and Hb (NO scavenger) significantly reduced carrageenan-induced paw edema and inhibited dose-dependently mechanical hyperalgesia in initial and second phase. L-Arginine (NO synthase substrate) significantly increased the paw volume and enhanced hyperalgesia. Only in gthe second phase of inflammation, not in the initial phase, aminoguanidine (inducible NOS selective inhibitor) reduced dose-dependently paw volume and inhibited mechanical hyperalgesia at the high dose. In CNS, L-NAME and Hb significantly inhibited mechanical hyperalgesia but L-arginine showed reverse tendency. From these results, it is suggested that endogenous No mediates the mechanical hyperalgesia and enhance the inflammatory edema in the inflammatory site and spinal cord. Especially the experiment performed with aminoguanidine shows that inducible NOS is implicated in the inflammatory edema and hyperalgesia phenomenon in the second phase of inflammation.
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KEYWORD
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